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TargetKynurenine 3-monooxygenase
LigandBDBM50072081
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1467952 (CHEMBL3413309)
IC50 72±n/a nM
Citation Toledo-Sherman, LMPrime, MEMrzljak, LBeconi, MGBeresford, ABrookfield, FABrown, CJCardaun, ICourtney, SMDijkman, UHamelin-Flegg, EJohnson, PDKempf, VLyons, KMatthews, KMitchell, WLO'Connell, CPena, PPowell, KRassoulpour, AReed, LReindl, WSelvaratnam, SFriley, WWWeddell, DAWent, NEWheelan, PWinkler, CWinkler, DWityak, JYarnold, CJYates, DMunoz-Sanjuan, IDominguez, C Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease. J Med Chem58:1159-83 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kynurenine 3-monooxygenase
Name:Kynurenine 3-monooxygenase
Synonyms:KMO_RAT | Kmo
Type:PROTEIN
Mol. Mass.:54371.88
Organism:Rattus norvegicus
Description:ChEMBL_1487468
Residue:478
Sequence:
MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVANFMRGRSINLALSY
RGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLT
AVESYPNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKK
PRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMS
FEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCV
LMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLS
MYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKK
VINRGLFVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTSGHWNRSADISPRVPWSH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50072081
n/a
NameBDBM50072081
Synonyms:CHEMBL3407922
TypeSmall organic molecule
Emp. Form.C14H11ClN2O3
Mol. Mass.290.702
SMILESOC(=O)c1cc(ncn1)-c1ccc(OC2CC2)c(Cl)c1
Structure
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