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TargetKynurenine 3-monooxygenase
LigandBDBM50061907
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1468212
IC50 900±n/a nM
Citation Toledo-Sherman LMPrime MEMrzljak LBeconi MGBeresford ABrookfield FABrown CJCardaun ICourtney SMDijkman UHamelin-Flegg EJohnson PDKempf VLyons KMatthews KMitchell WLO'Connell CPena PPowell KRassoulpour AReed LReindl WSelvaratnam SFriley WWWeddell DAWent NEWheelan PWinkler CWinkler DWityak JYarnold CJYates DMunoz-Sanjuan IDominguez C Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease. J Med Chem 58:1159-83 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kynurenine 3-monooxygenase
Name:Kynurenine 3-monooxygenase
Synonyms:Kmo | Kynurenine 3-hydroxylase | Kynurenine 3-monooxygenase
Type:PROTEIN
Mol. Mass.:54550.12
Organism:Mus musculus
Description:ChEMBL_109577
Residue:479
Sequence:
MASSDTQGKRVAVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVAKSARGRSINLALSY
RGRQALKAIGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISRENLNKDLLT
AVESYANAKVHFGHKLSKCIPEEGVLTVLGPDKVPRDVTCDLVVGCDGAYSTVRAHLMKK
PRFDYTQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAYMMIALPNMDKSFTCTLFMP
FEEFERLPTRSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSHCV
LMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNNLSMCLPEFSRFRIPDDHAISDLS
MYNYIEMRAHVNSRWFLFQKLLDKFLHAIMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKK
VINRGLFVLGSLIAIGGTYLLVHHLSLRPLEFLRRPAWMGTTGYWTRSTDISLQVPWSY
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  Blast E-value cutoff:
BDBM50061907
n/a
NameBDBM50061907
Synonyms:(+/-)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric acid[(+/-)-m-nicotinylbenzoylalanine] | 2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric acid | CHEMBL23983 | meta-nitrobenzoyl)alanine
TypeSmall organic molecule
Emp. Form.C10H10N2O5
Mol. Mass.238.1968
SMILESNC(CC(=O)c1cccc(c1)[N+]([O-])=O)C(O)=O
Structure
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