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TargetKynurenine 3-monooxygenase
LigandBDBM50072079
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1467938 (CHEMBL3413142)
IC50 0.700000±n/a nM
Citation Toledo-Sherman, LMPrime, MEMrzljak, LBeconi, MGBeresford, ABrookfield, FABrown, CJCardaun, ICourtney, SMDijkman, UHamelin-Flegg, EJohnson, PDKempf, VLyons, KMatthews, KMitchell, WLO'Connell, CPena, PPowell, KRassoulpour, AReed, LReindl, WSelvaratnam, SFriley, WWWeddell, DAWent, NEWheelan, PWinkler, CWinkler, DWityak, JYarnold, CJYates, DMunoz-Sanjuan, IDominguez, C Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease. J Med Chem58:1159-83 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kynurenine 3-monooxygenase
Name:Kynurenine 3-monooxygenase
Synonyms:KMO | KMO_HUMAN
Type:PROTEIN
Mol. Mass.:55831.03
Organism:Homo sapiens (Human)
Description:ChEMBL_1487479
Residue:486
Sequence:
MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSH
RGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLT
AAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKK
PRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMP
FEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCV
LLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLS
MYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKK
VINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQI
SNLISR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50072079
n/a
NameBDBM50072079
Synonyms:CHEMBL3407913
TypeSmall organic molecule
Emp. Form.C12H9ClN2O2
Mol. Mass.248.665
SMILESCc1ccc(cc1Cl)-c1cc(ncn1)C(O)=O
Structure
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