Reaction Details | |||
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Target | Serine/threonine-protein kinase Chk1 | ||
Ligand | BDBM17054 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1468651 (CHEMBL3413731) | ||
IC50 | 9.9±n/a nM | ||
Citation | Gomha, SM; Abdulla, MM; Abou-Seri, SM Identification of novel aminothiazole and aminothiadiazole conjugated cyanopyridines as selective CHK1 inhibitors. Eur J Med Chem92:459-70 (2015) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase Chk1 | |||
Name: | Serine/threonine-protein kinase Chk1 | ||
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 54443.02 | ||
Organism: | Homo sapiens (Human) | ||
Description: | gi_166295192 | ||
Residue: | 476 | ||
Sequence: |
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BDBM17054 | |||
n/a | |||
Name | BDBM17054 | ||
Synonyms: | (2S,3R,4R,6R,18R)-18-hydroxy-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one | (5S,6R,7R,9R,16R)-16-hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one | 7-Hydroxystaurosporine | UCN-01 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H26N4O4 | ||
Mol. Mass. | 482.5304 | ||
SMILES | [H][C@]12C[C@@H](NC)[C@@H](OC)[C@](C)(O1)n1c3ccccc3c3c4[C@@H](O)NC(=O)c4c4c5ccccc5n2c4c13 |r| | ||
Structure |