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TargetProton-coupled folate transporter
LigandBDBM50072398
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1469597 (CHEMBL3412692)
IC50>1000±n/a nM
Citation Wang, YMitchell-Ryan, SRaghavan, SGeorge, COrr, SHou, ZMatherly, LHGangjee, A Novel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents. J Med Chem58:1479-93 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Proton-coupled folate transporter
Name:Proton-coupled folate transporter
Synonyms:G21 | HCP1 | Heme carrier protein 1 | PCFT | PCFT/HCP1 | PCFT_HUMAN | SLC46A1 | Solute carrier family 46 member 1
Type:PROTEIN
Mol. Mass.:49782.13
Organism:Homo sapiens (Human)
Description:ChEMBL_1469597
Residue:459
Sequence:
MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGT
RQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLA
SLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFR
MALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKST
RLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWD
SKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFT
GYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNF
MKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50072398
n/a
NameBDBM50072398
Synonyms:CHEMBL2426245
TypeSmall organic molecule
Emp. Form.C17H17N5O6S
Mol. Mass.419.412
SMILESNc1nc2[nH]cc(Cc3ccc(s3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c2c(=O)[nH]1 |r|
Structure
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