Reaction Details |
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Target | Proton-coupled folate transporter |
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Ligand | BDBM50072398 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1469597 (CHEMBL3412692) |
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IC50 | >1000±n/a nM |
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Citation | Wang, Y; Mitchell-Ryan, S; Raghavan, S; George, C; Orr, S; Hou, Z; Matherly, LH; Gangjee, A Novel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents. J Med Chem58:1479-93 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Proton-coupled folate transporter |
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Name: | Proton-coupled folate transporter |
Synonyms: | G21 | HCP1 | Heme carrier protein 1 | PCFT | PCFT/HCP1 | PCFT_HUMAN | SLC46A1 | Solute carrier family 46 member 1 |
Type: | PROTEIN |
Mol. Mass.: | 49782.13 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1469597 |
Residue: | 459 |
Sequence: | MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGT
RQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLA
SLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFR
MALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKST
RLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWD
SKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFT
GYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNF
MKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
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BDBM50072398 |
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n/a |
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Name | BDBM50072398 |
Synonyms: | CHEMBL2426245 |
Type | Small organic molecule |
Emp. Form. | C17H17N5O6S |
Mol. Mass. | 419.412 |
SMILES | Nc1nc2[nH]cc(Cc3ccc(s3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c2c(=O)[nH]1 |r| |
Structure |
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