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TargetMitogen-activated protein kinase 1
LigandBDBM50072559
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1469629 (CHEMBL3412886)
Ki 0.700000±n/a nM
Citation Ren, LGrina, JMoreno, DBlake, JFGaudino, JJGarrey, RMetcalf, ATBurkard, MMartinson, MRasor, KChen, HDean, BGould, SEPacheco, PShahidi-Latham, SYin, JWest, KWang, WMoffat, JGSchwarz, JB Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2. J Med Chem58:1976-91 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 1
Name:Mitogen-activated protein kinase 1
Synonyms:ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:Ser/Thr Protein Kinase
Mol. Mass.:41392.76
Organism:Homo sapiens (Human)
Description:P28482
Residue:360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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BDBM50072559
n/a
NameBDBM50072559
Synonyms:CHEMBL3409569
TypeSmall organic molecule
Emp. Form.C21H20ClFN4O2
Mol. Mass.414.861
SMILESFc1cc(Cn2ccc(cc2=O)-c2ccnc(NC3CCOCC3)n2)ccc1Cl
Structure
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