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TargetCytochrome P450 2D6
LigandBDBM120086
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1469853 (CHEMBL3413964)
IC50>10000±n/a nM
Citation Ren, LGrina, JMoreno, DBlake, JFGaudino, JJGarrey, RMetcalf, ATBurkard, MMartinson, MRasor, KChen, HDean, BGould, SEPacheco, PShahidi-Latham, SYin, JWest, KWang, WMoffat, JGSchwarz, JB Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2. J Med Chem58:1976-91 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6
Name:Cytochrome P450 2D6
Synonyms:CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM120086
n/a
NameBDBM120086
Synonyms:US8697715, 1 | US9259470, 1
TypeSmall organic molecule
Emp. Form.C22H22ClFN4O3
Mol. Mass.444.886
SMILESOC[C@H](c1ccc(Cl)c(F)c1)n1ccc(cc1=O)-c1ccnc(NC2CCOCC2)n1 |r|
Structure
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