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TargetMitogen-activated protein kinase 1
LigandBDBM50072602
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1469629
Ki 0.100000±n/a nM
Citation Ren LGrina JMoreno DBlake JFGaudino JJGarrey RMetcalf ATBurkard MMartinson MRasor KChen HDean BGould SEPacheco PShahidi-Latham SYin JWest KWang WMoffat JGSchwarz JB Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2. J Med Chem 58:1976-91 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 1
Name:Mitogen-activated protein kinase 1
Synonyms:ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | p42-MAPK
Type:Ser/Thr Protein Kinase
Mol. Mass.:41392.76
Organism:Homo sapiens (Human)
Description:P28482
Residue:360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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  Blast E-value cutoff:
BDBM50072602
n/a
NameBDBM50072602
Synonyms:CHEMBL3409573
TypeSmall organic molecule
Emp. Form.C22H23ClN4O3
Mol. Mass.426.896
SMILESOCC(c1ccc(Cl)cc1)n1ccc(cc1=O)-c1ccnc(NC2CCOCC2)n1
Structure
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