| Reaction Details |
|---|
 | Report a problem with these data |
| Target | LIM domain kinase 1 |
|---|
| Ligand | BDBM50072670 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1467101 (CHEMBL3411298) |
|---|
| IC50 | 21±n/a nM |
|---|
| Citation |  Yin, Y; Zheng, K; Eid, N; Howard, S; Jeong, JH; Yi, F; Guo, J; Park, CM; Bibian, M; Wu, W; Hernandez, P; Park, H; Wu, Y; Luo, JL; LoGrasso, PV; Feng, Y Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors. J Med Chem58:1846-61 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| LIM domain kinase 1 |
|---|
| Name: | LIM domain kinase 1 |
|---|
| Synonyms: | LIMK | LIMK-1 | LIMK1 | LIMK1_HUMAN |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 72591.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_4505001 |
|---|
| Residue: | 647 |
|---|
| Sequence: | MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLS
HQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGD
GDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV
SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEID
LLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSID
RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE
TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT
LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFG
LARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC
EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL
EHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
|
|
|
|---|
| BDBM50072670 |
|---|
| n/a |
|---|
| Name | BDBM50072670 |
|---|
| Synonyms: | CHEMBL3410053 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H21ClFN5O2 |
|---|
| Mol. Mass. | 453.897 |
|---|
| SMILES | Cc1[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccc(Cl)cc4)c(F)c3)c2c1C |
|---|
| Structure | 
|
|---|
Search and Browse
