Reaction Details |
| Report a problem with these data |
Target | Dual specificity protein kinase TTK |
---|
Ligand | BDBM50072905 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1467136 (CHEMBL3411333) |
---|
IC50 | 2.6±n/a nM |
---|
Citation | Kusakabe, K; Ide, N; Daigo, Y; Itoh, T; Yamamoto, T; Hashizume, H; Nozu, K; Yoshida, H; Tadano, G; Tagashira, S; Higashino, K; Okano, Y; Sato, Y; Inoue, M; Iguchi, M; Kanazawa, T; Ishioka, Y; Dohi, K; Kido, Y; Sakamoto, S; Ando, S; Maeda, M; Higaki, M; Baba, Y; Nakamura, Y Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity. J Med Chem58:1760-75 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dual specificity protein kinase TTK |
---|
Name: | Dual specificity protein kinase TTK |
Synonyms: | Dual specificity protein kinase (TTK) | Dual specificity protein kinase TTK (MPS1) | MPS1 | MPS1L1 | Monopolar Spindle 1 (MPS1) | Monopolar Spindle 1 (Mps-1) | Monopolar Spindle 1 Kinase (MPS1) | Phosphotyrosine picked threonine-protein kinase (MPS1) | TTK | TTK_HUMAN |
Type: | Protein |
Mol. Mass.: | 97086.79 |
Organism: | Homo sapiens (Human) |
Description: | P33981 |
Residue: | 857 |
Sequence: | MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMAN
NPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELK
AIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEML
EIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARF
LYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQ
TSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKT
ESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQ
KHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQ
LSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVF
QVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYM
VMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML
KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL
GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI
SIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGE
SHNSSSSKTFEKKRGKK
|
|
|
BDBM50072905 |
---|
n/a |
---|
Name | BDBM50072905 |
Synonyms: | CHEMBL3410078 |
Type | Small organic molecule |
Emp. Form. | C28H29N5O4 |
Mol. Mass. | 499.561 |
SMILES | Oc1ccccc1Oc1cc(NCC2CCOCC2)c2ncc(-c3ccc(cc3)C(=O)NC3CC3)n2n1 |
Structure |
|