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TargetTranslocator protein
LigandBDBM50073596
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1467416 (CHEMBL3411700)
Ki 0.310000±n/a nM
Citation Banister, SDBeinat, CWilkinson, SMShen, BBartoli, CSelleri, SDa Pozzo, EMartini, CChin, FTKassiou, M Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO). Eur J Med Chem93:392-400 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Translocator protein
Name:Translocator protein
Synonyms:Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:Mitochondrion membrane protein
Mol. Mass.:18945.84
Organism:Rattus norvegicus (rat)
Description:Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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  Blast E-value cutoff:
BDBM50073596
n/a
NameBDBM50073596
Synonyms:CHEMBL3408967
TypeSmall organic molecule
Emp. Form.C27H29FN4O2
Mol. Mass.460.5432
SMILESCCN(CC)C(=O)Cc1c(nn2c(C)cc(C)nc12)-c1ccc(OCc2ccccc2F)cc1
Structure
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