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TargetProtein arginine methyltransferase 3 (PRMT3)
LigandBDBM50427768
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1473725
IC50 1600±n/a nM
Citation Kaniskan HÜKonze KDJin J Selective inhibitors of protein methyltransferases. J Med Chem 58:1596-629 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein arginine methyltransferase 3 (PRMT3)
Name:Protein arginine N-methyltransferase 3
Synonyms:Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | Protein arginine N-methyltransferase 3 | Protein arginine N-methyltransferase 3 (PRMT3)
Type:Protein
Mol. Mass.:59859.85
Organism:Homo sapiens (Human)
Description:n/a
Residue:531
Sequence:
MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSA
EETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEY
LKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAR
EDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRT
ESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLN
KLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYP
DICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIK
HIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHW
KQTVFLLEKPFSVKAGEALKGKVTVHKSKKDPRSLTVTLTLNNSTQTYGLQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50427768
n/a
NameBDBM50427768
Synonyms:CHEMBL2325441
TypeSmall organic molecule
Emp. Form.C15H18N4OS
Mol. Mass.302.395
SMILESO=C(NCCC1=CCCCC1)Nc1ccc2nnsc2c1 |t:5|
Structure
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