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TargetIntegrase
LigandBDBM50075208
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1473740 (CHEMBL3418257)
IC50 4400±n/a nM
Citation Vernekar, SKLiu, ZNagy, EMiller, LKirby, KAWilson, DJKankanala, JSarafianos, SGParniak, MAWang, Z Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities. J Med Chem58:651-64 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Integrase
Name:Integrase
Synonyms:pol
Type:PROTEIN
Mol. Mass.:32203.43
Organism:Human immunodeficiency virus 1
Description:ChEMBL_106649
Residue:288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50075208
n/a
NameBDBM50075208
Synonyms:CHEMBL3414860
TypeSmall organic molecule
Emp. Form.C16H12ClNO3
Mol. Mass.301.724
SMILESON1C(=O)Cc2cc(Cc3ccc(Cl)cc3)ccc2C1=O
Structure
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