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TargetReverse transcriptase
LigandBDBM50075295
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1473731 (CHEMBL3418037)
IC50 1900±n/a nM
Citation Vernekar, SKLiu, ZNagy, EMiller, LKirby, KAWilson, DJKankanala, JSarafianos, SGParniak, MAWang, Z Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities. J Med Chem58:651-64 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Reverse transcriptase
Name:Reverse transcriptase
Synonyms:n/a
Type:Protein
Mol. Mass.:29598.37
Organism:Human immunodeficiency virus 1
Description:Q9WKE8
Residue:254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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  Blast E-value cutoff:
BDBM50075295
n/a
NameBDBM50075295
Synonyms:CHEMBL3414875
TypeSmall organic molecule
Emp. Form.C23H18FNO4
Mol. Mass.391.3917
SMILESCOc1ccc(cc1F)-c1ccc(Cc2ccc3C(=O)N(O)C(=O)Cc3c2)cc1
Structure
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