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TargetReverse transcriptase
LigandBDBM33410
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1473731
IC50>25000±n/a nM
Citation Vernekar SKLiu ZNagy EMiller LKirby KAWilson DJKankanala JSarafianos SGParniak MAWang Z Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities. J Med Chem 58:651-64 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Reverse transcriptase
Name:Reverse transcriptase
Synonyms:n/a
Type:Protein
Mol. Mass.:29598.37
Organism:Human immunodeficiency virus 1
Description:Q9WKE8
Residue:254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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  Blast E-value cutoff:
BDBM33410
n/a
NameBDBM33410
Synonyms:CHEMBL16755 | N-hydroxyisoquinolinedione, 2
TypeSmall organic molecule
Emp. Form.C9H7NO3
Mol. Mass.177.1568
SMILESON1C(=O)Cc2ccccc2C1=O
Structure
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