| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM50075210 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1473735 (CHEMBL3418041) |
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| IC50 | 2500±n/a nM |
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| Citation |  Vernekar, SK; Liu, Z; Nagy, E; Miller, L; Kirby, KA; Wilson, DJ; Kankanala, J; Sarafianos, SG; Parniak, MA; Wang, Z Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities. J Med Chem58:651-64 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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| BDBM50075210 |
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| n/a |
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| Name | BDBM50075210 |
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| Synonyms: | CHEMBL3414867 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16FNO3 |
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| Mol. Mass. | 361.3657 |
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| SMILES | ON1C(=O)Cc2cc(Cc3ccc(cc3)-c3ccc(F)cc3)ccc2C1=O |
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| Structure | 
|
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