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TargetTyrosine-protein kinase Blk
LigandBDBM50075730
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1473547 (CHEMBL3420426)
IC50 32±n/a nM
Citation Ellis, JMAltman, MDBass, AButcher, JWByford, AJDonofrio, AGalloway, SHaidle, AMJewell, JKelly, NLeccese, EKLee, SMaddess, MMiller, JRMoy, LYOsimboni, EOtte, RDReddy, MVSpencer, KSun, BVincent, SHWard, GJWoo, GHYang, CHoushyar, HNorthrup, AB Overcoming mutagenicity and ion channel activity: optimization of selective spleen tyrosine kinase inhibitors. J Med Chem58:1929-39 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase Blk
Name:Tyrosine-protein kinase Blk
Synonyms:B lymphoid tyrosine kinase | BLK | BLK_HUMAN | SRC | Tyrosine-protein kinase BLK (BLK) | p55-Blk
Type:Protein
Mol. Mass.:57711.88
Organism:Homo sapiens (Human)
Description:P51451
Residue:505
Sequence:
MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK
HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE
MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR
CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS
LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY
AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD
LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS
FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER
PTFEFLQSVLEDFYTATERQYELQP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50075730
n/a
NameBDBM50075730
Synonyms:CHEMBL3415599
TypeSmall organic molecule
Emp. Form.C18H24N6O4S
Mol. Mass.420.486
SMILESCOc1cc(C)nc(Nc2cc(N[C@@H]3CS(=O)(=O)CC[C@@H]3N)cnc2C(N)=O)c1 |r|
Structure
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