| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM33409 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1473838 (CHEMBL3418915) |
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| IC50 | 3200±n/a nM |
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| Citation |  Cuzzucoli Crucitti, G; Métifiot, M; Pescatori, L; Messore, A; Madia, VN; Pupo, G; Saccoliti, F; Scipione, L; Tortorella, S; Esposito, F; Corona, A; Cadeddu, M; Marchand, C; Pommier, Y; Tramontano, E; Costi, R; Di Santo, R Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain. J Med Chem58:1915-28 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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| BDBM33409 |
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| n/a |
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| Name | BDBM33409 |
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| Synonyms: | alpha, gamma-diketo acid, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11NO5S |
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| Mol. Mass. | 317.317 |
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| SMILES | OC(=O)C(=O)CC(=O)c1ccc(NC(=O)c2ccccc2)s1 |
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| Structure | 
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