| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 6 |
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| Ligand | BDBM50076185 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1473907 (CHEMBL3419158) |
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| Kd | 110±n/a nM |
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| Citation |  Thoma, G; Smith, AB; van Eis, MJ; Vangrevelinghe, E; Blanz, J; Aichholz, R; Littlewood-Evans, A; Lee, CC; Liu, H; Zerwes, HG Discovery and profiling of a selective and efficacious Syk inhibitor. J Med Chem58:1950-63 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PAK 6 |
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| Name: | Serine/threonine-protein kinase PAK 6 |
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| Synonyms: | PAK5 | PAK6 | PAK6_HUMAN | Serine/threonine-protein kinase PAK5 | Serine/threonine-protein kinase PAK6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74897.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1513397 |
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| Residue: | 681 |
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| Sequence: | MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRIT
RVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDE
HWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSL
GPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGR
PGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPP
SLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIS
TSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGI
VCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVL
MEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRV
KLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPP
YFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQ
TGLPECLVPLIQLYRKQTSTC
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| BDBM50076185 |
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| n/a |
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| Name | BDBM50076185 |
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| Synonyms: | CHEMBL3416026 | US9290481, 1.1 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22N8O |
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| Mol. Mass. | 366.4203 |
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| SMILES | N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3cc[nH]c23)n1 |r| |
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| Structure | 
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