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TargetMitogen-activated protein kinase kinase kinase 2
LigandBDBM50076185
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1473904 (CHEMBL3419155)
Kd 140±n/a nM
Citation Thoma, GSmith, ABvan Eis, MJVangrevelinghe, EBlanz, JAichholz, RLittlewood-Evans, ALee, CCLiu, HZerwes, HG Discovery and profiling of a selective and efficacious Syk inhibitor. J Med Chem58:1950-63 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase kinase kinase 2
Name:Mitogen-activated protein kinase kinase kinase 2
Synonyms:M3K2_HUMAN | MAP3K2 | MAPK/ERK kinase kinase 2 | MAPKKK2 | MEK kinase 2 | MEKK 2 | MEKK2
Type:PROTEIN
Mol. Mass.:69751.14
Organism:Homo sapiens (Human)
Description:ChEMBL_1473904
Residue:619
Sequence:
MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFP
RPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLV
INGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARN
GSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSY
PDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVS
FSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGK
LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQ
YYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIV
HRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGR
KADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVE
AKLRPSADELLRHMFVHYH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50076185
n/a
NameBDBM50076185
Synonyms:CHEMBL3416026 | US9290481, 1.1
TypeSmall organic molecule
Emp. Form.C18H22N8O
Mol. Mass.366.4203
SMILESN[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3cc[nH]c23)n1 |r|
Structure
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