Reaction Details |
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Target | Mitogen-activated protein kinase kinase kinase 2 |
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Ligand | BDBM50076185 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1473904 (CHEMBL3419155) |
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Kd | 140±n/a nM |
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Citation | Thoma, G; Smith, AB; van Eis, MJ; Vangrevelinghe, E; Blanz, J; Aichholz, R; Littlewood-Evans, A; Lee, CC; Liu, H; Zerwes, HG Discovery and profiling of a selective and efficacious Syk inhibitor. J Med Chem58:1950-63 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase kinase kinase 2 |
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Name: | Mitogen-activated protein kinase kinase kinase 2 |
Synonyms: | M3K2_HUMAN | MAP3K2 | MAPK/ERK kinase kinase 2 | MAPKKK2 | MEK kinase 2 | MEKK 2 | MEKK2 |
Type: | PROTEIN |
Mol. Mass.: | 69751.14 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1473904 |
Residue: | 619 |
Sequence: | MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFP
RPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLV
INGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARN
GSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSY
PDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVS
FSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGK
LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQ
YYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIV
HRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGR
KADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVE
AKLRPSADELLRHMFVHYH
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BDBM50076185 |
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n/a |
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Name | BDBM50076185 |
Synonyms: | CHEMBL3416026 | US9290481, 1.1 |
Type | Small organic molecule |
Emp. Form. | C18H22N8O |
Mol. Mass. | 366.4203 |
SMILES | N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3cc[nH]c23)n1 |r| |
Structure |
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