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TargetSphingosine kinase 1
LigandBDBM50077145
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1474026 (CHEMBL3419997)
Ki>10000±n/a nM
Citation Patwardhan, NNMorris, EAKharel, YRaje, MRGao, MTomsig, JLLynch, KRSantos, WL Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors. J Med Chem58:1879-99 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine kinase 1
Name:Sphingosine kinase 1
Synonyms:SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1)
Type:Enzyme
Mol. Mass.:42521.16
Organism:Homo sapiens (Human)
Description:Q9NYA1
Residue:384
Sequence:
MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHA
RELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASL
NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE
SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP
LEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLL
RLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFW
MVSGCVEPPPSWKPQQMPPPEEPL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50077145
n/a
NameBDBM50077145
Synonyms:CHEMBL3416836
TypeSmall organic molecule
Emp. Form.C21H32ClN5O2
Mol. Mass.421.964
SMILESCl.[H][C@]1(C[C@@H](O)CN1C(N)=N)c1nc(no1)-c1ccc(CCCCCCCC)cc1 |r|
Structure
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