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TargetSphingosine kinase 2
LigandBDBM50077147
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1474027 (CHEMBL3419998)
Ki>10000±n/a nM
Citation Patwardhan, NNMorris, EAKharel, YRaje, MRGao, MTomsig, JLLynch, KRSantos, WL Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors. J Med Chem58:1879-99 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine kinase 2
Name:Sphingosine kinase 2
Synonyms:SK 2 | SK2 | SPHK2 | SPHK2_HUMAN | SPK 2 | Sphingosine kinase 2 | Sphingosine kinase types 2 (SphK2)
Type:Protein
Mol. Mass.:69221.44
Organism:Homo sapiens (Human)
Description:Q9NRA0
Residue:654
Sequence:
MNGHLEAEEQQDQRPDQELTGSWGHGPRSTLVRAKAMAPPPPPLAASTPLLHGEFGSYPA
RGPRFALTLTSQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTY
PRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRP
PRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDG
IVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDL
LLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTL
GTVLGLATLHTYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSV
SDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKA
ALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFVL
MLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQL
GYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50077147
n/a
NameBDBM50077147
Synonyms:CHEMBL3416846
TypeSmall organic molecule
Emp. Form.C22H34ClN5O
Mol. Mass.419.991
SMILESCl.CCCCCCCCc1ccc(cc1)-c1noc(C[C@@H]2CCCN2C(N)=N)n1 |r|
Structure
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