| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator BAX |
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| Ligand | BDBM50078017 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1471766 (CHEMBL3417877) |
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| Ki | 12900±n/a nM |
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| Citation |  Stornaiuolo, M; La Regina, G; Passacantilli, S; Grassia, G; Coluccia, A; La Pietra, V; Giustiniano, M; Cassese, H; Di Maro, S; Brancaccio, D; Taliani, S; Ialenti, A; Silvestri, R; Martini, C; Novellino, E; Marinelli, L Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents. J Med Chem58:2135-48 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator BAX |
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| Name: | Apoptosis regulator BAX |
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| Synonyms: | Apoptosis regulator BAX | BAX | BAX_HUMAN | BCL2L4 | Bcl-2-like protein 4 | Bcl2-L-4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21181.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_100916 |
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| Residue: | 192 |
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| Sequence: | MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLS
ECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKL
VLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGV
LTASLTIWKKMG
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| BDBM50078017 |
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| n/a |
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| Name | BDBM50078017 |
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| Synonyms: | CHEMBL3417397 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H19N3OS |
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| Mol. Mass. | 421.514 |
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| SMILES | CC1=NN(C(=O)\C1=C\c1ccc(cc1)-c1ccccc1)c1nc(cs1)-c1ccccc1 |t:1| |
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| Structure | 
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