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TargetArachidonate 5-lipoxygenase-activating protein
LigandBDBM50078118
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1471925 (CHEMBL3420840)
IC50 1.1±n/a nM
Citation Takahashi, HRiether, DBartolozzi, ABosanac, TBerger, VBinetti, RBroadwater, JChen, ZCrux, RDe Lombaert, SDave, RDines, JAFadra-Khan, TFlegg, AGarrigou, MHao, MHHuber, JHutzler, JMKerr, SKotey, ALiu, WLo, HYLoke, PLMahaney, PEMorwick, TMNapier, SOlague, APack, EPadyana, AKThomson, DSTye, HWu, LZindell, RMAbeywardane, ASimpson, T Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915). J Med Chem58:1669-90 (2015) [PubMed]  Article
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Arachidonate 5-lipoxygenase-activating protein
Name:Arachidonate 5-lipoxygenase-activating protein
Synonyms:5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:Enzyme
Mol. Mass.:18159.90
Organism:Homo sapiens (Human)
Description:P20292
Residue:161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50078118
n/a
NameBDBM50078118
Synonyms:CHEMBL3417524
TypeSmall organic molecule
Emp. Form.C25H27N7O2
Mol. Mass.457.5276
SMILESCN(C)C(=O)Cn1cc(cn1)-c1nc(no1)[C@](C)(C1CC1)c1ccc(cc1)-c1ccc(N)nc1 |r|
Structure
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