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TargetInduced myeloid leukemia cell differentiation protein Mcl-1
LigandBDBM50424734
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1472592
Ki 340±n/a nM
Citation Bruncko MWang LSheppard GSPhillips DCTahir SKXue JErickson SFidanze SFry EHasvold LJenkins GJJin SJudge RAKovar PJMadar DNimmer PPark CPetros AMRosenberg SHSmith MLSong XSun CTao ZFWang XXiao YZhang HTse CLeverson JDElmore SWSouers AJ Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity. J Med Chem 58:2180-94 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Induced myeloid leukemia cell differentiation protein Mcl-1
Name:Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:Membrane; Single-pass membrane protein
Mol. Mass.:37332.87
Organism:Homo sapiens (Human)
Description:n/a
Residue:350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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  Blast E-value cutoff:
BDBM50424734
n/a
NameBDBM50424734
Synonyms:CHEMBL2314198
TypeSmall organic molecule
Emp. Form.C22H19NO3
Mol. Mass.345.3912
SMILESOC(=O)c1[nH]c2ccccc2c1CCCOc1cccc2ccccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: