| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Ligand | BDBM50078151 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1472593 (CHEMBL3417958) |
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| Ki | 8600±n/a nM |
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| Citation |  Bruncko, M; Wang, L; Sheppard, GS; Phillips, DC; Tahir, SK; Xue, J; Erickson, S; Fidanze, S; Fry, E; Hasvold, L; Jenkins, GJ; Jin, S; Judge, RA; Kovar, PJ; Madar, D; Nimmer, P; Park, C; Petros, AM; Rosenberg, SH; Smith, ML; Song, X; Sun, C; Tao, ZF; Wang, X; Xiao, Y; Zhang, H; Tse, C; Leverson, JD; Elmore, SW; Souers, AJ Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity. J Med Chem58:2180-94 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
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| Type: | Membrane; Single-pass membrane protein |
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| Mol. Mass.: | 37332.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820 |
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| Residue: | 350 |
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| Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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| BDBM50078151 |
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| n/a |
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| Name | BDBM50078151 |
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| Synonyms: | CHEMBL3417691 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H25NO3 |
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| Mol. Mass. | 435.5137 |
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| SMILES | Cc1ccccc1-c1cccc2c(CCCOc3cccc4ccccc34)c([nH]c12)C(O)=O |
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| Structure | 
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