| Reaction Details |
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 | Report a problem with these data |
| Target | PH domain leucine-rich repeat-containing protein phosphatase 1 |
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| Ligand | BDBM50078209 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1470574 (CHEMBL3419800) |
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| Kd | 720±n/a nM |
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| Citation |  Yan, R; Chuang, HC; Kapuriya, N; Chou, CC; Lai, PT; Chang, HW; Yang, CN; Kulp, SK; Chen, CS Exploitation of the ability of¿-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitors. J Med Chem58:2290-8 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| PH domain leucine-rich repeat-containing protein phosphatase 1 |
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| Name: | PH domain leucine-rich repeat-containing protein phosphatase 1 |
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| Synonyms: | KIAA0606 | KIAA0606 | PH domain leucine-rich repeat-containing protein phosphatase 1 | PH domain-containing family E member 1 | PHLP1_HUMAN | PHLPP | PHLPP1 | PLEKHE1 | Pleckstrin homology domain-containing family E member 1 | SCOP | Suprachiasmatic nucleus circadian oscillatory protein | hSCOP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 184662.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109588 |
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| Residue: | 1717 |
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| Sequence: | MEPAAAATVQRLPELGREDRASAPAAAAAAAAAAAAAAAALAAAAGGGRSPEPALTPAAP
SGGNGSGSGAREEAPGEAPPGPLPGRAGGAGRRRRRGAPQPIAGGAAPVPGAGGGANSLL
LRRGRLKRNLSAAAAAASSSSSSSAAAASHSPGAAGLPASCSASASLCTRSLDRKTLLLK
HRQTLQLQPSDRDWVRHQLQRGCVHVFDRHMASTYLRPVLCTLDTTAGEVAARLLQLGHK
GGGVVKVLGQGPGAAAAREPAEPPPEAGPRLAPPEPRDSEVPPARSAPGAFGGPPRAPPA
DLPLPVGGPGGWSRRASPAPSDSSPGEPFVGGPVSSPRAPRPVVSDTESFSLSPSAESVS
DRLDPYSSGGGSSSSSEELEADAASAPTGVPGQPRRPGHPAQPLPLPQTASSPQPQQKAP
RAIDSPGGAVREGSCEEKAAAAVAPGGLQSTPGRSGVTAEKAPPPPPPPTLYVQLHGETT
RRLEAEEKPLQIQNDYLFQLGFGELWRVQEEGMDSEIGCLIRFYAGKPHSTGSSERIQLS
GMYNVRKGKMQLPVNRWTRRQVILCGTCLIVSSVKDSLTGKMHVLPLIGGKVEEVKKHQH
CLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVASQRISSVDLSCCSLEHLPANLFYSQ
DLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELN
VSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLE
KLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRD
NKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMD
VSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLE
RTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLT
NNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIM
NCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNPR
LVLDHKTLELLNNIRCFKIDQPSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCD
NREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQK
LGGAAVLCHIKHDPVDPGGSFTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIK
QHKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSL
SVEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISAVVVQLSVTEDSFCCCELSAGGAV
PPPSPGIFPPSVNMVIKDRPSDGLGVPSSSSGMASEISSELSTSEMSSEVGSTASDEPPP
GALSENSPAYPSEQRCMLHPICLSNSFQRQLSSATFSSAFSDNGLDSDDEEPIEGVFTNG
SRVEVEVDIHCSRAKEKEKQQHLLQVPAEASDEGIVISANEDEPGLPRKADFSAVGTIGR
RRANGSVAPQERSHNVIEVATDAPLRKPGGYFAAPAQPDPDDQFIIPPELEEEVKEIMKH
HQEQQQQQQPPPPPQLQPQLPRHYQLDQLPDYYDTPL
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| BDBM50078209 |
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| n/a |
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| Name | BDBM50078209 |
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| Synonyms: | CHEMBL3414686 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H29NO3S |
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| Mol. Mass. | 339.493 |
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| SMILES | CC(C)CCCC1(C)CCc2cc(c(C)c(C)c2O1)S(N)(=O)=O |
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| Structure | 
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