| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50078670 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1471415 (CHEMBL3419422) |
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| IC50 | 156±n/a nM |
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| Citation |  Huang, Q; Rui, EY; Cobbs, M; Dinh, DM; Gukasyan, HJ; Lafontaine, JA; Mehta, S; Patterson, BD; Rewolinski, DA; Richardson, PF; Edwards, MP Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressure. J Med Chem58:2821-33 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50078670 |
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| n/a |
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| Name | BDBM50078670 |
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| Synonyms: | CHEMBL3415381 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H15N3O7S3 |
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| Mol. Mass. | 385.437 |
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| SMILES | CCN[C@H]1C[C@H](CO[N+]([O-])=O)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r| |
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| Structure | 
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