| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50078757 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1471609 (CHEMBL3420550) |
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| IC50 | 120±n/a nM |
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| Citation |  Lin, X; Chen, W; Qiu, Z; Guo, L; Zhu, W; Li, W; Wang, Z; Zhang, W; Zhang, Z; Rong, Y; Zhang, M; Yu, L; Zhong, S; Zhao, R; Wu, X; Wong, JC; Tang, G Design and synthesis of orally bioavailable aminopyrrolidinone histone deacetylase 6 inhibitors. J Med Chem58:2809-20 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50078757 |
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| n/a |
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| Name | BDBM50078757 |
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| Synonyms: | CHEMBL3415453 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16ClN3O3 |
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| Mol. Mass. | 345.78 |
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| SMILES | ONC(=O)c1ccc(NC2CCN(C2=O)c2ccc(Cl)cc2)cc1 |
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| Structure | 
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