| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] B |
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| Ligand | BDBM50346863 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1472636 (CHEMBL3418205) |
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| IC50 | 8980±n/a nM |
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| Citation |  Valente, S; Rodriguez, V; Mercurio, C; Vianello, P; Saponara, B; Cirilli, R; Ciossani, G; Labella, D; Marrocco, B; Monaldi, D; Ruoppolo, G; Tilset, M; Botrugno, OA; Dessanti, P; Minucci, S; Mattevi, A; Varasi, M; Mai, A Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts. Eur J Med Chem94:163-74 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amine oxidase [flavin-containing] B |
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| Name: | Amine oxidase [flavin-containing] B |
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| Synonyms: | AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB) |
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| Type: | Protein |
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| Mol. Mass.: | 58768.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P27338 |
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| Residue: | 520 |
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| Sequence: | MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWR
TMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ
TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVY
YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEER
LKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT
FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
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| BDBM50346863 |
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| n/a |
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| Name | BDBM50346863 |
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| Synonyms: | CHEMBL1797640 | US8765820, 5b |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N2O |
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| Mol. Mass. | 252.311 |
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| SMILES | NC1CC1c1ccc(NC(=O)c2ccccc2)cc1 |
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| Structure | 
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