Reaction Details |
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Target | 5-hydroxytryptamine receptor 4 |
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Ligand | BDBM50079375 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1470633 (CHEMBL3420220) |
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Ki | 0.950000±n/a nM |
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Citation | Rochais, C; Lecoutey, C; Gaven, F; Giannoni, P; Hamidouche, K; Hedou, D; Dubost, E; Genest, D; Yahiaoui, S; Freret, T; Bouet, V; Dauphin, F; Sopkova de Oliveira Santos, J; Ballandonne, C; Corvaisier, S; Malzert-Fréon, A; Legay, R; Boulouard, M; Claeysen, S; Dallemagne, P Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride. J Med Chem58:3172-87 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 4 |
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Name: | 5-hydroxytryptamine receptor 4 |
Synonyms: | 5-HT4 | 5-hydroxytryptamine receptor 4 | 5HT4R_CAVPO | HTR4 | Serotonin 4 (5-HT4) receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 43735.29 |
Organism: | GUINEA PIG |
Description: | 5-HT4 HTR4 GUINEA PIG::O70528 |
Residue: | 388 |
Sequence: | MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRP
QPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
TVECGGQWESQCHPAASSPLVAAQPIDT
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BDBM50079375 |
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n/a |
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Name | BDBM50079375 |
Synonyms: | CHEMBL3417008 | US9663465, 20 |
Type | Small organic molecule |
Emp. Form. | C21H31ClN2O3 |
Mol. Mass. | 394.935 |
SMILES | COc1cc(N)c(Cl)cc1C(=O)OCC1CCN(CC2CCCCC2)CC1 |
Structure |
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