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Target5-hydroxytryptamine receptor 4
LigandBDBM50079375
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1470633 (CHEMBL3420220)
Ki 0.950000±n/a nM
Citation Rochais, CLecoutey, CGaven, FGiannoni, PHamidouche, KHedou, DDubost, EGenest, DYahiaoui, SFreret, TBouet, VDauphin, FSopkova de Oliveira Santos, JBallandonne, CCorvaisier, SMalzert-Fréon, ALegay, RBoulouard, MClaeysen, SDallemagne, P Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride. J Med Chem58:3172-87 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 4
Name:5-hydroxytryptamine receptor 4
Synonyms:5-HT4 | 5-hydroxytryptamine receptor 4 | 5HT4R_CAVPO | HTR4 | Serotonin 4 (5-HT4) receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:43735.29
Organism:GUINEA PIG
Description:5-HT4 HTR4 GUINEA PIG::O70528
Residue:388
Sequence:
MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRP
QPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
TVECGGQWESQCHPAASSPLVAAQPIDT
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  Blast E-value cutoff:
BDBM50079375
n/a
NameBDBM50079375
Synonyms:CHEMBL3417008 | US9663465, 20
TypeSmall organic molecule
Emp. Form.C21H31ClN2O3
Mol. Mass.394.935
SMILESCOc1cc(N)c(Cl)cc1C(=O)OCC1CCN(CC2CCCCC2)CC1
Structure
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