Reaction Details |
| Report a problem with these data |
Target | MAP kinase-interacting serine/threonine-protein kinase 1 |
---|
Ligand | BDBM50079403 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1470960 (CHEMBL3419828) |
---|
Ki | 2150±n/a nM |
---|
Citation | Yu, M; Li, P; Basnet, SK; Kumarasiri, M; Diab, S; Teo, T; Albrecht, H; Wang, S Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d]pyrimidine derivatives as potent Mnk inhibitors: synthesis, structure-activity relationship analysis and biological evaluation. Eur J Med Chem95:116-26 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
MAP kinase-interacting serine/threonine-protein kinase 1 |
---|
Name: | MAP kinase-interacting serine/threonine-protein kinase 1 |
Synonyms: | MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 51342.85 |
Organism: | Homo sapiens (Human) |
Description: | Q9BUB5 |
Residue: | 465 |
Sequence: | MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS
GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL
AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
|
|
|
BDBM50079403 |
---|
n/a |
---|
Name | BDBM50079403 |
Synonyms: | CHEMBL3417207 |
Type | Small organic molecule |
Emp. Form. | C14H12N4O3S |
Mol. Mass. | 316.335 |
SMILES | Cc1c(sc2ncnc(Nc3ccc(=O)n(C)c3)c12)C(O)=O |
Structure |
|