| Reaction Details |
|---|
 | Report a problem with these data |
| Target | MAP kinase-interacting serine/threonine-protein kinase 1 |
|---|
| Ligand | BDBM50079468 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1470960 (CHEMBL3419828) |
|---|
| Ki | >10000±n/a nM |
|---|
| Citation |  Yu, M; Li, P; Basnet, SK; Kumarasiri, M; Diab, S; Teo, T; Albrecht, H; Wang, S Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d]pyrimidine derivatives as potent Mnk inhibitors: synthesis, structure-activity relationship analysis and biological evaluation. Eur J Med Chem95:116-26 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| MAP kinase-interacting serine/threonine-protein kinase 1 |
|---|
| Name: | MAP kinase-interacting serine/threonine-protein kinase 1 |
|---|
| Synonyms: | MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 51342.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9BUB5 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS
GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL
AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
|
|
|
|---|
| BDBM50079468 |
|---|
| n/a |
|---|
| Name | BDBM50079468 |
|---|
| Synonyms: | CHEMBL3417201 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H17N5O2S |
|---|
| Mol. Mass. | 343.403 |
|---|
| SMILES | CNC(=O)c1sc2ncnc(Nc3cc(C)cn(C)c3=O)c2c1C |
|---|
| Structure | 
|
|---|
Search and Browse
