| Reaction Details |
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 | Report a problem with these data |
| Target | Heme oxygenase 1 |
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| Ligand | BDBM50079977 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1470660 (CHEMBL3420247) |
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| IC50 | 900±n/a nM |
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| Citation |  Salerno, L; Pittalą, V; Romeo, G; Modica, MN; Marrazzo, A; Siracusa, MA; Sorrenti, V; Di Giacomo, C; Vanella, L; Parayath, NN; Greish, K Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. Eur J Med Chem96:162-72 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heme oxygenase 1 |
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| Name: | Heme oxygenase 1 |
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| Synonyms: | HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 33005.15 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | HO-1 obtained from rat spleen was used in enzyme assays. |
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| Residue: | 289 |
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| Sequence: | MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTA
LEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHE
VGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQ
LYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRP
ASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
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| BDBM50079977 |
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| n/a |
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| Name | BDBM50079977 |
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| Synonyms: | CHEMBL3415248 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H13N3S2 |
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| Mol. Mass. | 275.392 |
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| SMILES | C(CSc1nc2ccccc2s1)Cn1ccnc1 |
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| Structure | 
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