| Reaction Details |
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 | Report a problem with these data |
| Target | Heme oxygenase 2 |
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| Ligand | BDBM50079989 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1470661 (CHEMBL3420440) |
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| IC50 | 900±n/a nM |
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| Citation |  Salerno, L; Pittalą, V; Romeo, G; Modica, MN; Marrazzo, A; Siracusa, MA; Sorrenti, V; Di Giacomo, C; Vanella, L; Parayath, NN; Greish, K Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. Eur J Med Chem96:162-72 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heme oxygenase 2 |
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| Name: | Heme oxygenase 2 |
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| Synonyms: | HMOX2_RAT | Heme Oxygenase 2 (HO-2) | Heme oxygenase 2 | Hmox2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 35754.99 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | HO-2 obtained from rat brain was used in enzyme assays. |
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| Residue: | 315 |
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| Sequence: | MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGN
IKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENW
EEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTG
EGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAG
SMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILA
ASVALVAGLLAWYYM
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| BDBM50079989 |
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| n/a |
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| Name | BDBM50079989 |
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| Synonyms: | CHEMBL3415253 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16ClN3S2 |
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| Mol. Mass. | 337.891 |
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| SMILES | Clc1ccc2sc(SCCCCCn3ccnc3)nc2c1 |
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| Structure | 
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