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TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B
LigandBDBM30202
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1475745 (CHEMBL3424978)
IC50 43±n/a nM
Citation Kettle, JGBallard, PBardelle, CCockerill, MColclough, NCritchlow, SEDebreczeni, JFairley, GFillery, SGraham, MAGoodwin, LGuichard, SHudson, KWard, RAWhittaker, D Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J Med Chem58:2834-44 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Name:Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Synonyms:DYR1B_HUMAN | DYRK1B | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Dual-specificity tyrosine-regulated kinases 1B | MIRK
Type:Enzyme
Mol. Mass.:69222.24
Organism:Homo sapiens (Human)
Description:Q9Y463
Residue:629
Sequence:
MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI
SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
PPLPPPDDPATLGPHLGLRGVPQSTAASS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM30202
n/a
NameBDBM30202
Synonyms:Pyrrolopyridine, 33
TypeSmall organic molecule
Emp. Form.C24H24N4O2
Mol. Mass.400.473
SMILESO=C(NC1CCCC1)c1ccc(cc1)-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1
Structure
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