| Reaction Details |
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 | Report a problem with these data |
| Target | Glycine receptor subunit alpha-1 |
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| Ligand | BDBM50416875 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1474520 (CHEMBL3423809) |
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| EC50 | 320±n/a nM |
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| Citation |  Wells, MM; Tillman, TS; Mowrey, DD; Sun, T; Xu, Y; Tang, P Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptora1 for the treatment of pain. J Med Chem58:2958-66 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycine receptor subunit alpha-1 |
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| Name: | Glycine receptor subunit alpha-1 |
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| Synonyms: | GLRA1 | GLRA1_HUMAN | Glycine receptor 48 kDa subunit | Glycine receptor strychnine-binding subunit |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52635.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23415 |
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| Residue: | 457 |
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| Sequence: | MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF
KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS
IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC
IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA
RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA
SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF
QEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA
KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
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| BDBM50416875 |
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| n/a |
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| Name | BDBM50416875 |
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| Synonyms: | AMG-073 | AMG073 HCL | CINACALCET | CINACALCET HYDROCHLORIDE | US9487494, Cinacalcet |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22F3N |
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| Mol. Mass. | 357.412 |
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| SMILES | C[C@@H](NCCCc1cccc(c1)C(F)(F)F)c1cccc2ccccc12 |r| |
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| Structure | 
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