Reaction Details |
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Target | Neuronal acetylcholine receptor subunit alpha-7 |
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Ligand | BDBM50319936 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1475131 (CHEMBL3424809) |
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Ki | 5.9±n/a nM |
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Citation | Beinat, C; Reekie, T; Banister, SD; O'Brien-Brown, J; Xie, T; Olson, TT; Xiao, Y; Harvey, A; O'Connor, S; Coles, C; Grishin, A; Kolesik, P; Tsanaktsidis, J; Kassiou, M Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities ata7 nAChRs through incorporation of known structural motifs. Eur J Med Chem95:277-301 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neuronal acetylcholine receptor subunit alpha-7 |
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Name: | Neuronal acetylcholine receptor subunit alpha-7 |
Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) |
Type: | Enzyme |
Mol. Mass.: | 56502.44 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q05941 |
Residue: | 502 |
Sequence: | MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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BDBM50319936 |
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n/a |
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Name | BDBM50319936 |
Synonyms: | (1S,4S)-2-methyl-5-(6-phenylpyridazin-3-yl)-2,5-diazabicyclo[2.2.1]heptane | CHEMBL1082655 |
Type | Small organic molecule |
Emp. Form. | C16H18N4 |
Mol. Mass. | 266.3409 |
SMILES | CN1C[C@@H]2C[C@H]1CN2c1ccc(nn1)-c1ccccc1 |r| |
Structure |
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