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Target6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
LigandBDBM50082120
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1475279 (CHEMBL3425139)
IC50 3570±n/a nM
Citation Boyd, SBrookfield, JLCritchlow, SECumming, IACurtis, NJDebreczeni, JDegorce, SLDonald, CEvans, NJGroombridge, SHopcroft, PJones, NPKettle, JGLamont, SLewis, HJMacFaull, PMcLoughlin, SBRigoreau, LJSmith, JMSt-Gallay, SStock, JKTurnbull, APWheatley, ERWinter, JWingfield, J Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3. J Med Chem58:3611-25 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Name:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Synonyms:6-phosphofructo-2-kinase | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 | 6PF-2-K/Fru-2,6-P2ase 2 | 6PF-2-K/Fru-2,6-P2ase heart-type isozyme | F262_HUMAN | Fructose-2,6-bisphosphatase | PFK/FBPase 2 | PFKFB2
Type:PROTEIN
Mol. Mass.:58485.20
Organism:Homo sapiens (Human)
Description:ChEMBL_109607
Residue:505
Sequence:
MSGASSSEQNNNSYETKTPNLRMSEKKCSWASYMTNSPTLIVMIGLPARGKTYVSKKLTR
YLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEE
NGQIAVFDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPE
RNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVY
YLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVW
TSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRY
PGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTI
FKLTPVAYGCKVETIKLNVEAVNTHRDKPTNNFPKNQTPVRMRRNSFTPLSSSNTIRRPR
NYSVGSRPLKPLSPLRAQDMQEGAD
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  Blast E-value cutoff:
BDBM50082120
n/a
NameBDBM50082120
Synonyms:CHEMBL3422680
TypeSmall organic molecule
Emp. Form.C23H23N5O2
Mol. Mass.401.461
SMILESCn1cc(cn1)-c1c[nH]c2ccc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)cc12 |r|
Structure
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