| Reaction Details |
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 | Report a problem with these data |
| Target | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
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| Ligand | BDBM50082112 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1475334 (CHEMBL3425231) |
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| IC50 | 633±n/a nM |
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| Citation |  Boyd, S; Brookfield, JL; Critchlow, SE; Cumming, IA; Curtis, NJ; Debreczeni, J; Degorce, SL; Donald, C; Evans, NJ; Groombridge, S; Hopcroft, P; Jones, NP; Kettle, JG; Lamont, S; Lewis, HJ; MacFaull, P; McLoughlin, SB; Rigoreau, LJ; Smith, JM; St-Gallay, S; Stock, JK; Turnbull, AP; Wheatley, ER; Winter, J; Wingfield, J Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3. J Med Chem58:3611-25 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
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| Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
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| Synonyms: | 6-phosphofructo-2-kinase | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) | 6PF-2-K/Fru-2,6-P2ase 3 | 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme | F263_HUMAN | Fructose-2,6-bisphosphatase | PFK/FBPase 3 | PFKFB3 | Renal carcinoma antigen NY-REN-56 | iPFK-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 59620.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16875 |
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| Residue: | 520 |
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| Sequence: | MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLN
WIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQ
IAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNS
AEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLM
NIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQ
LKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTG
ESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKL
TPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFE
EHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH
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| BDBM50082112 |
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| n/a |
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| Name | BDBM50082112 |
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| Synonyms: | CHEMBL3422672 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28N4O3 |
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| Mol. Mass. | 444.5255 |
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| SMILES | O=C(Nc1ccc(Oc2ccc3n(CC4CCOCC4)cc(C#N)c3c2)cc1)[C@@H]1CCCN1 |r| |
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| Structure | 
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