Reaction Details |
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Target | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 |
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Ligand | BDBM50082139 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1475279 (CHEMBL3425139) |
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IC50 | 24890±n/a nM |
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Citation | Boyd, S; Brookfield, JL; Critchlow, SE; Cumming, IA; Curtis, NJ; Debreczeni, J; Degorce, SL; Donald, C; Evans, NJ; Groombridge, S; Hopcroft, P; Jones, NP; Kettle, JG; Lamont, S; Lewis, HJ; MacFaull, P; McLoughlin, SB; Rigoreau, LJ; Smith, JM; St-Gallay, S; Stock, JK; Turnbull, AP; Wheatley, ER; Winter, J; Wingfield, J Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3. J Med Chem58:3611-25 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 |
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Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 |
Synonyms: | 6-phosphofructo-2-kinase | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 | 6PF-2-K/Fru-2,6-P2ase 2 | 6PF-2-K/Fru-2,6-P2ase heart-type isozyme | F262_HUMAN | Fructose-2,6-bisphosphatase | PFK/FBPase 2 | PFKFB2 |
Type: | PROTEIN |
Mol. Mass.: | 58485.20 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_109607 |
Residue: | 505 |
Sequence: | MSGASSSEQNNNSYETKTPNLRMSEKKCSWASYMTNSPTLIVMIGLPARGKTYVSKKLTR
YLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEE
NGQIAVFDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPE
RNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVY
YLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVW
TSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRY
PGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTI
FKLTPVAYGCKVETIKLNVEAVNTHRDKPTNNFPKNQTPVRMRRNSFTPLSSSNTIRRPR
NYSVGSRPLKPLSPLRAQDMQEGAD
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BDBM50082139 |
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n/a |
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Name | BDBM50082139 |
Synonyms: | CHEMBL3422662 |
Type | Small organic molecule |
Emp. Form. | C20H20N4O2 |
Mol. Mass. | 348.3984 |
SMILES | CCn1cc(C#N)c2cc(Oc3ccc(NC(=O)CNC)cc3)ccc12 |
Structure |
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