Reaction Details |
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Target | Farnesyl pyrophosphate synthase |
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Ligand | BDBM50226002 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1474098 (CHEMBL3424031) |
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IC50 | 200000±n/a nM |
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Citation | Zhou, X; Born, EJ; Allen, C; Holstein, SA; Wiemer, DF N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation. Bioorg Med Chem Lett25:2331-4 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Farnesyl pyrophosphate synthase |
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Name: | Farnesyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
Type: | Enzyme |
Mol. Mass.: | 48272.89 |
Organism: | Homo sapiens (Human) |
Description: | P14324 |
Residue: | 419 |
Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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BDBM50226002 |
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n/a |
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Name | BDBM50226002 |
Synonyms: | (R)-2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid | 2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid | 3-(3-Pyridyl)-2-hydroxy-2-phosphonopropanoic acid | CHEMBL397829 |
Type | Small organic molecule |
Emp. Form. | C8H10NO6P |
Mol. Mass. | 247.1419 |
SMILES | OC(=O)C(O)(Cc1cccnc1)P(O)(O)=O |
Structure |
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