| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-glutamine gamma-glutamyltransferase 2 (TG2) |
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| Ligand | BDBM50083722 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1475047 |
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| IC50 | 9.6±n/a nM |
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| Citation |  Avery CA; Pease RJ; Smith K; Boothby M; Buckley HM; Grant PJ; Fishwick CW (±) cis-Bisamido epoxides: A novel series of potent FXIII-A inhibitors. Eur J Med Chem 98:49-53 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-glutamine gamma-glutamyltransferase 2 (TG2) |
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| Name: | Protein-glutamine gamma-glutamyltransferase 2 (TG2) |
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| Synonyms: | Protein-glutamine gamma-glutamyltransferase | Tissue transglutaminase | Tissue transglutaminase (TG2) | Transglutaminase 2 (TGM2) | Transglutaminase C | Transglutaminase-2 |
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| Type: | Protein |
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| Mol. Mass.: | 77309.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21980 |
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| Residue: | 687 |
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| Sequence: | MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFS
VVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLE
ASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPW
NFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGR
WDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTN
YNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPT
PQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSL
IVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVG
QSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEK
SVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQK
RKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMG
LHKLVVNFESDKLKAVKGFRNVIIGPA
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| BDBM50083722 |
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| n/a |
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| Name | BDBM50083722 |
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| Synonyms: | CHEMBL3423198 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H8BrClN2O3 |
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| Mol. Mass. | 319.539 |
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| SMILES | NC(=O)[C@@H]1O[C@@H]1C(=O)Nc1ccc(Br)c(Cl)c1 |r| |
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| Structure | 
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