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TargetProstaglandin D Synthase
LigandBDBM50084259
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1477164
IC50 48±n/a nM
Citation Edfeldt FEvenäs JLepistö MWard APetersen JWissler LRohman MSivars USvensson KPerry MFeierberg IZhou XHHansson TNarjes F Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS). Bioorg Med Chem Lett 25:2496-500 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin D Synthase
Name:Prostaglandin D Synthase
Synonyms:Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | Prostaglandin D
Type:Enzyme
Mol. Mass.:23341.07
Organism:Homo sapiens (Human)
Description:The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLT
LHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL
TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKK
VQAIPAVANWIKRRPQTKL
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  Blast E-value cutoff:
BDBM50084259
n/a
NameBDBM50084259
Synonyms:CHEMBL3425960
TypeSmall organic molecule
Emp. Form.C18H25F3N4O
Mol. Mass.370.4125
SMILESFC(F)(F)CN1CCC(CC1)NC(=O)c1ccc(nc1)N1CCCCC1
Structure
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