| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Catechol O-methyltransferase |
|---|
| Ligand | BDBM50086210 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1477937 (CHEMBL3429504) |
|---|
| IC50 | 19±n/a nM |
|---|
| Citation |  Harrison, ST; Poslusney, MS; Mulhearn, JJ; Zhao, Z; Kett, NR; Schubert, JW; Melamed, JY; Allison, TJ; Patel, SB; Sanders, JM; Sharma, S; Smith, RF; Hall, DL; Robinson, RG; Sachs, NA; Hutson, PH; Wolkenberg, SE; Barrow, JC Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT). ACS Med Chem Lett6:318-23 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Catechol O-methyltransferase |
|---|
| Name: | Catechol O-methyltransferase |
|---|
| Synonyms: | COMT_RAT | Catechol O-methyltransferase | Catechol-O-methyltransferase | Comt |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 29594.09 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | n/a |
|---|
| Residue: | 264 |
|---|
| Sequence: | MPLAAVSLGLLLLALLLLLRHLGWGLVTIFWFEYVLQPVHNLIMGDTKEQRILRYVQQNA
KPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMA
RLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDM
VFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSY
LEYMKVVDGLEKAIYQGPSSPDKS
|
|
|
|---|
| BDBM50086210 |
|---|
| n/a |
|---|
| Name | BDBM50086210 |
|---|
| Synonyms: | CHEMBL3425739 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H19NO3 |
|---|
| Mol. Mass. | 369.4126 |
|---|
| SMILES | OC(c1ccccc1)c1cc(=O)c(O)cn1-c1cccc(c1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
