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TargetCatechol O-methyltransferase
LigandBDBM50086212
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1477937 (CHEMBL3429504)
IC50 77±n/a nM
Citation Harrison, STPoslusney, MSMulhearn, JJZhao, ZKett, NRSchubert, JWMelamed, JYAllison, TJPatel, SBSanders, JMSharma, SSmith, RFHall, DLRobinson, RGSachs, NAHutson, PHWolkenberg, SEBarrow, JC Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT). ACS Med Chem Lett6:318-23 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Catechol O-methyltransferase
Name:Catechol O-methyltransferase
Synonyms:COMT_RAT | Catechol O-methyltransferase | Catechol-O-methyltransferase | Comt
Type:Enzyme
Mol. Mass.:29594.09
Organism:Rattus norvegicus (Rat)
Description:n/a
Residue:264
Sequence:
MPLAAVSLGLLLLALLLLLRHLGWGLVTIFWFEYVLQPVHNLIMGDTKEQRILRYVQQNA
KPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMA
RLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDM
VFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSY
LEYMKVVDGLEKAIYQGPSSPDKS
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  Blast E-value cutoff:
BDBM50086212
n/a
NameBDBM50086212
Synonyms:CHEMBL3425737
TypeSmall organic molecule
Emp. Form.C20H19NO2
Mol. Mass.305.3704
SMILESCC(C)c1cc(=O)c(O)cn1-c1cccc(c1)-c1ccccc1
Structure
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