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TargetCatechol O-methyltransferase (MB-COMT)
LigandBDBM50086211
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1477938
IC50 1400±n/a nM
Citation Harrison STPoslusney MSMulhearn JJZhao ZKett NRSchubert JWMelamed JYAllison TJPatel SBSanders JMSharma SSmith RFHall DLRobinson RGSachs NAHutson PHWolkenberg SEBarrow JC Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT). ACS Med Chem Lett 6:318-23 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Catechol O-methyltransferase (MB-COMT)
Name:Catechol O-methyltransferase
Synonyms:Catechol O-methyltransferase
Type:Enzyme
Mol. Mass.:30030.67
Organism:Homo sapiens (Human)
Description:P21964
Residue:271
Sequence:
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL
NHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCG
YSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKY
DVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFE
CTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
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  Blast E-value cutoff:
BDBM50086211
n/a
NameBDBM50086211
Synonyms:CHEMBL3425738
TypeSmall organic molecule
Emp. Form.C19H17NO3
Mol. Mass.307.3432
SMILESCC(O)c1cc(=O)c(O)cn1-c1cccc(c1)-c1ccccc1
Structure
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