| Reaction Details |
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 | Report a problem with these data |
| Target | Farnesyl pyrophosphate synthase |
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| Ligand | BDBM50098382 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1478084 (CHEMBL3430146) |
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| IC50 | 363±n/a nM |
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| Citation |  Liu, YL; Cao, R; Wang, Y; Oldfield, E Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries. ACS Med Chem Lett6:349-54 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Farnesyl pyrophosphate synthase |
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| Name: | Farnesyl pyrophosphate synthase |
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| Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48272.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14324 |
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| Residue: | 419 |
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| Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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| BDBM50098382 |
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| n/a |
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| Name | BDBM50098382 |
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| Synonyms: | (1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phosphonic acid | (1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phosphonic acid(NE58051,homorisedronate) | 1-hydroxy-3-(pyridin-3-yl)propane-1,1-diyldiphosphonic acid | 3-(3-Hydroxy-3,3-bis-phosphono-propyl)-pyridinium | 3-(3-hydrogen phosphonato-3-hydroxy-3-phosphonatopropyl)pyridin-1-ium | 3-(3-pyridyl)-1-hydroxy-propane-1,1-bisphosphonate | CHEMBL293522 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H13NO7P2 |
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| Mol. Mass. | 297.1388 |
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| SMILES | OC(CCc1cccnc1)(P(O)(O)=O)P(O)(O)=O |
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| Structure | 
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