Ki Summary

Reaction Details

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Target

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Ligand

BDBM50086319

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1476004 (CHEMBL3428360)

IC50

9.0±n/a nM

Citation

Haffner, CD; Becherer, JD; Boros, EE; Cadilla, R; Carpenter, T; Cowan, D; Deaton, DN; Guo, Y; Harrington, W; Henke, BR; Jeune, MR; Kaldor, I; Milliken, N; Petrov, KG; Preugschat, F; Schulte, C; Shearer, BG; Shearer, T; Smalley, TL; Stewart, EL; Stuart, JD; Ulrich, JC Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors. J Med Chem58:3548-71 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Name:

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Synonyms:

Type:

PROTEIN

Mol. Mass.:

34417.04

Organism:

Mus musculus

Description:

ChEMBL_109609

Residue:

304

Sequence:

MANYEFSQVSGDRPGCRLSRKAQIGLGVGLLVLIALVVGIVVILLRPRSLLVWTGEPTTK
HFSDIFLGRCLIYTQILRPEMRDQNCQEILSTFKGAFVSKNPCNITREDYAPLVKLVTQT
IPCNKTLFWSKSKHLAHQYTWIQGKMFTLEDTLLGYIADDLRWCGDPSTSDMNYVSCPHW
SENCPNNPITVFWKVISQKFAEDACGVVQVMLNGSLREPFYKNSTFGSVEVFSLDPNKVH
KLQAWVMHDIEGASSNACSSSSLNELKMIVQKRNMIFACVDNYRPARFLQCVKNPEHPSC
RLNT

BDBM50086319

n/a

Name

BDBM50086319

Synonyms:

CHEMBL3426191

Type

Small organic molecule

Emp. Form.

C18H19N5OS

Mol. Mass.

353.441

SMILES

NC(=O)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncs1 |r,wU:3.2,wD:6.9,(6.69,7.37,;6.68,6.14,;7.75,5.52,;5.34,5.38,;5.34,3.84,;4,3.07,;2.67,3.85,;2.68,5.39,;4.01,6.15,;1.33,3.08,;1.33,1.54,;2.66,.77,;2.66,-.77,;1.33,-1.54,;,-.77,;-1.33,-1.54,;-2.68,-.77,;-2.68,.77,;-1.33,1.54,;,.77,;-4.01,1.54,;-5.4,.91,;-6.43,2.07,;-5.65,3.39,;-4.14,3.06,)|

Structure