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TargetLymphocyte differentiation antigen CD38
LigandBDBM50086335
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1476003
IC50 4.8±n/a nM
Citation Haffner CDBecherer JDBoros EECadilla RCarpenter TCowan DDeaton DNGuo YHarrington WHenke BRJeune MRKaldor IMilliken NPetrov KGPreugschat FSchulte CShearer BGShearer TSmalley TLStewart ELStuart JDUlrich JC Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors. J Med Chem 58:3548-71 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lymphocyte differentiation antigen CD38
Name:Lymphocyte differentiation antigen CD38
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:34333.62
Organism:Homo sapiens (Human)
Description:ChEMBL_1509931
Residue:300
Sequence:
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFP
ETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCN
KILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDC
SNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEA
WVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50086335
n/a
NameBDBM50086335
Synonyms:CHEMBL3426066
TypeSmall organic molecule
Emp. Form.C21H24N4O2S
Mol. Mass.396.506
SMILESCNC(=O)[C@H]1CC[C@@H](CC1)Nc1cc(=O)n(C)c2ccc(cc12)-c1cncs1 |r,wU:4.3,wD:7.10,(9.08,5.97,;8.01,5.36,;6.68,6.14,;6.69,7.37,;5.34,5.38,;5.34,3.84,;4,3.07,;2.67,3.85,;2.68,5.39,;4.01,6.15,;1.33,3.08,;1.33,1.54,;2.66,.77,;2.66,-.77,;3.73,-1.38,;1.33,-1.54,;1.33,-2.77,;,-.77,;-1.33,-1.54,;-2.68,-.77,;-2.68,.77,;-1.33,1.54,;,.77,;-4.01,1.54,;-5.4,.91,;-6.43,2.07,;-5.65,3.39,;-4.14,3.06,)|
Structure
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